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101.
Dr. Ayumi Hirano‐Iwata Yutaka Ishinari Dr. Hideaki Yamamoto Prof. Michio Niwano 《化学:亚洲杂志》2015,10(6):1266-1274
Ion channel proteins provide gated pores that allow ions to passively flow across cell membranes. Owing to their crucial roles in regulating transmembrane ion flow, ion channel proteins have attracted the attention of pharmaceutical investigators as drug targets for use in the studies of both therapeutics and side effects. In this review, we discuss the current technologies that are used in the formation of ion channel‐integrated bilayer lipid membranes (BLMs) in microfabricated devices as a potential platform for next‐generation drug screening systems. Advances in BLM fabrication methodology have allowed the preparation of BLMs in sophisticated formats, such as microfluidic, automated, and/or array systems, which can be combined with channel current recordings. A much more critical step is the integration of the target channels into BLMs. Current technologies for the functional reconstitution of ion channel proteins are presented and discussed. Finally, the remaining issues of the BLM‐based methods for recording ion channel activities and their potential applications as drug screening systems are discussed. 相似文献
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104.
该文总结了二次离子质谱、基质辅助激光解吸电离质谱和常压敞开式离子化质谱三大类型质谱分子成像(MSI)技术的概况、技术与方法及其应用新进展。MSI技术作为免标记、高覆盖、高灵敏、检测范围广的可视化分析手段,不局限于生物组织或细胞中某种特定分子的检测,可对已知和未知多种分子进行同时成像分析,获得不同分子的空间分布、相对含量及结构信息,实现其分子的定性、定量与定位分析;还可提供不同生理及病理过程中功能分子的动态时空变化信息等。因此,MSI技术成为质谱领域以及分析化学等领域的研究前沿与热点方向之一,并在化学、医学、生命科学、药学和环境科学等领域显示出重大应用前景。此外,MSI技术是单细胞可视化分析和空间分辨代谢组学的强有力分析手段,可从动物或器官组织的整体、微区、单细胞等不同空间尺度,获取具有空间分布特征、时空动态变化的功能分子全景轮廓信息等而备受关注。 相似文献
105.
商业化锂离子电池石墨负极和锂盐过渡金属氧化物正极材料的储锂容量都已接近各自的理论值,探索下一代高能量密度电极材料是解决现阶段锂离子电池容量限制的关键。近年来,新型金属草酸基负极材料,借助其在金属离子电池中多元化储能机制诱发的较高储能效应在碱金属离子电池绿色储能材料领域备受关注。本文就金属草酸基材料在锂、钠、钾金属离子电池方面的最新研究进行了综述,着重介绍了材料的晶型结构、多元化储能机制及储能过程中的动力学特征,简单阐述了材料在电化学储能中存在的问题,分析了金属草酸基负极材料在形貌晶型控制、界面碳复合改性和金属元素掺杂方面的改性策略。最后,预测了金属草酸基负极材料在碱金属离子电池体系的发展方向。 相似文献
106.
应用零价铁(ZVI)去除水中(类)金属(含氧)离子是近年来研究的热点。在ZVI除污染过程中,同步提升ZVI除污的反应活性与电子效率对该技术进一步推广应用至关重要。本文综述了近十年(2011-2021年)ZVI的提升技术,主要涉及硫化、外加弱磁场、投加Fe2+、投加氧化剂以及其他新型技术。从不同体系广谱研究以及单一体系具体研究的角度,系统分析了这些技术对ZVI去除含氧水体中(类)金属(含氧)离子的反应活性、去除容量、电子效率的提升表现及作用机制。最后,对ZVI技术未来的研究方向作出了展望,以期促进ZVI技术的进一步完善与发展。本文有望为增强零价铁去除污染物的实际效能提供新的探索方向并完备相关理论基础。 相似文献
107.
Simone Madama Ermelinda Falletta Amir Mohammad Malvandi Kevin Arzoni Carlo Brogna Marco Varelli Matteo Bertelli Matteo Conti Martina Larini Federico Guidugli Pietro Traldi Simone Cristoni 《Journal of mass spectrometry : JMS》2022,57(8):e4876
In this work, the isolation step in the linear ion trap was performed using different “q values” conditions at a low collision-induced dissociation (CID) energy leading to the parent ion resolution improvements, reasonably due to better ion energy distribution. According to the results, we obtained a greater resolution and mass accuracy operating in both traditional electrospray and low voltage ionization near the q value = 0.778 and with a CID energy of 10%. This effect was evaluated with low-molecular-mass compounds (skatole and arginine). The proposed optimization yielded a superior instrument performance without adding technological complexity to mass spectrometry analyses. 相似文献
108.
Prof. Christopher J. Patridge 《Chemphyschem》2022,23(2):e202100674
Multivalent ion storage and aqueous electrochemical systems continue to build interest for energy application. The Zn-ion system with 2 electron transfer and an ideal metal anode is a strong candidate but is still at the early stage of development. Using both in situ near-edge (XANES) and X-ray absorption fine structure spectroscopy, EXAFS, a nanostructured cathode material, CaxV2O5-H2O (CVO), was probed at the V-K absorption edge. This operando study reveals the local electronic and geometric structure changes for CVO during galvanostatic cycling as the active material in an aqueous Zn-ion cell. The XANES data provides a fine resolution to track the evolution of the vanadium oxidative state and near-neighbor coordination sphere showing subtle shifts and delocalized charge. The Zn-ion influence on the V-K absorption edge is visualized using a difference technique called Δμ. Coupled with theoretical calculations and modelling, the extended region extracted local bonding information further confirms excellent electronic and structural reversibility of this vanadium oxide bronze in an aqueous Zn-ion electrochemical cell. 相似文献
109.
This study is aimed to establish a simple, rapid, and accurate ion chromatography approach for the simultaneous detection of six inorganic anions in urine. Various performance parameters affecting the determination of anions were optimized, including the selection of sample protein precipitation agent, eluent, and flow rate. The final eluent was 3.6 mmol/L sodium carbonate and 12% isopropanol with a flow rate of 0.6 mL/min. Acetonitrile was used for pretreatment to precipitate proteins, and the volume ratio of urine to acetonitrile was 1:4. The correlation coefficient of the target anion calibration curve ranged from 0.9973 to 0.9999. The limit of detection ranged from 1.50 to 12.0 μg/L, and the method detection limit ranged from 15.0 to 120 μg/L. The standard recovery rate for low, medium, and high concentrations ranged from 90 to 110%. The inter-day and intra-day relative standard deviations were <5%. The method has high accuracy and good reproducibility and is suitable for the separation and determination of anions in urine. 相似文献
110.
Annija Lace Aideen Byrne Simon Bluett Laurent Malaquin Vincent Raimbault Remi Courson Zain Hayat Breda Moore Eoin Murray 《Journal of separation science》2022,45(5):1042-1050
An ion chromatography system employing a low-cost three-dimensional printed absorbance detector for indirect ultraviolet detection towards portable phosphate analysis of environmental and industrial waters has been developed. The optical detection cell was fabricated using stereolithography three-dimensional printing of nanocomposite material. Chromatographic analysis and detection of phosphate were carried out using a CS5A 4 × 250 mm analytical column with indirect ultraviolet detection using a 255 nm light-emitting diode. Isocratic elution using a 0.6 mM potassium phthalate eluent combined with 1.44 mM sodium bicarbonate was employed at a flow rate of 0.75 mL/min. A linear calibration range of 0.5 to 30 mg/L PO43− applicable to environmental and wastewater analysis was achieved. For retention time and peak area repeatability, relative standard deviation values were 0.68 and 4.09%, respectively. Environmental and wastewater samples were analyzed with the optimized ion chromatography platform and the results were compared to values obtained by an accredited ion chromatograph. For the analysis of environmental samples, relative errors of <14 % were achieved. Recovery analysis was also carried out on both freshwater and wastewater samples and recovery results were within the acceptable range for water analysis using standard ion chromatography methods. 相似文献